Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	904	4q35.1	TLR3	toll like receptor 3
Mouse	1	905	8 B1.1	Tlr3	toll-like receptor 3
Rat	-	-	16q11	Tlr3	toll-like receptor 3

Previous and Unofficial Names

toll-like receptor 3 | CD283 | IIAE2

Database Links
Alphafold	O15455 (Hs), Q99MB1 (Mm)
CATH/Gene3D	3.80.10.10, 3.40.50.10140
ChEMBL Target	CHEMBL1075113 (Hs), CHEMBL2146340 (Mm)
Ensembl Gene	ENSG00000164342 (Hs), ENSMUSG00000031639 (Mm), ENSRNOG00000021726 (Rn)
Entrez Gene	7098 (Hs), 142980 (Mm), 364594 (Rn)
Human Protein Atlas	ENSG00000164342 (Hs)
KEGG Gene	hsa:7098 (Hs), mmu:142980 (Mm), rno:364594 (Rn)
OMIM	603029 (Hs)
Pharos	O15455 (Hs)
UniProtKB	O15455 (Hs), Q99MB1 (Mm)
Wikipedia	TLR3 (Hs)

Activator Comments

Poly(I:C) activation of TLR3 is assessed by its ability to induce cytokine production or activation of NF-κB and mitogen-activated protein (MAP) kinases [1].

Immunopharmacology Comments

TLR3 is an endosomal anti-viral receptor [2], with potent pro-inflammatory actions (e.g. induction of Type I IFN and pro-inflammatory cytokines, including IL-6, TNF, IL-17, IL-21, IP-10 and RANTES). Innate Pharma are developing IPH33 as an anti-TLR3 anti-inflammatory biologic, which acts upstream relative to current therapies such as anti-TNF and anti-IL-6 mAbs and small molecule JAK inhibitors.

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 3 GO processes GO:0002224 toll-like receptor signaling pathway IDA GO:0034138 toll-like receptor 3 signaling pathway IDA click arrow to show/hide IEA associations GO:0001774 microglial cell activation IEA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 1 GO processes GO:0032722 positive regulation of chemokine production IDA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 16 GO processes GO:0032722 positive regulation of chemokine production IDA GO:0032727 positive regulation of interferon-alpha production IDA GO:0032728 positive regulation of interferon-beta production IDA GO:0032729 positive regulation of type II interferon production IDA GO:0032735 positive regulation of interleukin-12 production ISS GO:0032755 positive regulation of interleukin-6 production IDA GO:0032757 positive regulation of interleukin-8 production IDA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0034138 toll-like receptor 3 signaling pathway IDA click arrow to show/hide IEA associations GO:0002730 regulation of dendritic cell cytokine production IEA GO:0034343 type III interferon production IEA GO:0034346 positive regulation of type III interferon production IEA GO:0035458 cellular response to interferon-beta IEA GO:0060907 positive regulation of macrophage cytokine production IEA GO:0071346 cellular response to type II interferon IEA GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 7 GO processes GO:0002224 toll-like receptor signaling pathway IDA GO:0034138 toll-like receptor 3 signaling pathway IDA GO:0045671 negative regulation of osteoclast differentiation NAS GO:0050729 positive regulation of inflammatory response IC click arrow to show/hide IEA associations GO:0002730 regulation of dendritic cell cytokine production IEA GO:0060907 positive regulation of macrophage cytokine production IEA GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA

Immuno Process:  Tissue repair GO Annotations:  Associated to 1 GO processes GO:0090594 inflammatory response to wounding IDA

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0045671 negative regulation of osteoclast differentiation NAS

Immuno Process:  Inflammation GO Annotations:  Associated to 9 GO processes GO:0002224 toll-like receptor signaling pathway IDA GO:0034138 toll-like receptor 3 signaling pathway IDA GO:0038187 pattern recognition receptor activity IDA GO:0045087 innate immune response TAS GO:0050729 positive regulation of inflammatory response IC GO:0090594 inflammatory response to wounding IDA click arrow to show/hide IEA associations GO:0001774 microglial cell activation IEA GO:0071346 cellular response to type II interferon IEA GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA

Clinically-Relevant Mutations and Pathophysiology
Disease:  Cervical cancer Disease Ontology: DOID:4362 OMIM: 603956
Disease:  Colorectal cancer Disease Ontology: DOID:9256 OMIM: 114500
Disease:  Herpes simplex encephalitis, susceptibility to, 2 Synonyms: Herpes simplex virus encephalitis [Disease Ontology: DOID:0050181] Herpetic encephalitis [Orphanet: ORPHA1930] Disease Ontology: DOID:0050181 OMIM: 613002 Orphanet: ORPHA1930
Disease:  Human immunodeficiency virus type 1, susceptibility to Synonyms: Human immunodeficiency virus infectious disease [Disease Ontology: DOID:526] Disease Ontology: DOID:526 OMIM: 609423 Orphanet: ORPHA319269
Disease:  Macular degeneration, age-related, 1; ARMD1 Synonyms: Age-related macular degeneration [Orphanet: ORPHA279] [Disease Ontology: DOID:10871] Disease Ontology: DOID:10871 OMIM: 603075 Orphanet: ORPHA279
Disease:  Stevens-Johnson syndrome Synonyms: Severe cutaneous adverse reaction, susceptibility to [OMIM: 608579] Disease Ontology: DOID:0050426 OMIM: 608579 Orphanet: ORPHA36426