Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	419	5q32	GPR151	G protein-coupled receptor 151
Mouse	7	422	18 B3	Gpr151	G protein-coupled receptor 151
Rat	7	421	18p11	Gpr151	G protein-coupled receptor 151

Previous and Unofficial Names

GALR4 | G-protein coupled receptor PGR7 | galanin receptor 4

Database Links
Specialist databases
GPCRdb	gp151_human (Hs), gp151_mouse (Mm), gp151_rat (Rn)
Other databases
Alphafold	Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
ChEMBL Target	CHEMBL3085617 (Hs)
Ensembl Gene	ENSG00000173250 (Hs), ENSMUSG00000042816 (Mm), ENSRNOG00000027103 (Rn)
Entrez Gene	134391 (Hs), 240239 (Mm), 307475 (Rn)
Human Protein Atlas	ENSG00000173250 (Hs)
KEGG Gene	hsa:134391 (Hs), mmu:240239 (Mm), rno:307475 (Rn)
Pharos	Q8TDV0 (Hs)
RefSeq Nucleotide	NM_194251 (Hs), NM_181543 (Mm), NM_181633 (Rn)
RefSeq Protein	NP_919227 (Hs), NP_853521 (Mm), NP_853664 (Rn)
UniProtKB	Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
Wikipedia	GPR151 (Hs)

Agonist Comments

GPR151 responded to galanin with an EC50 value of 2 uM. This suggests that the endogenous ligand shares structural features with galanin [1].

Immuno Process Associations

Immuno Process:  Immune regulation GO Annotations:  Associated to 1 GO processes GO:0050778 positive regulation of immune response ISS

Tissue Distribution
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach Species:  Human Technique:  Northern blot References:  1
Central nervous system and habenular complex Species:  Mouse Technique:  in situ hybridisation References:  1
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach Species:  Mouse Technique:  Northern blot References:  1

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Phenotypes, Alleles and Disease Models	Mouse data from MGI
Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Gpr151tm1Dgen Gpr151tm1Dgen/Gpr151tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:2441887  MP:0002169 no abnormal phenotype detected

Biologically Significant Variants
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  L261V Global MAF (%):  36 Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 23|22|80|19 Minor allele count:  C=0.363/792 SNP accession:  rs7709485 Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  P40L Global MAF (%):  4 Subpopulation MAF (%):  AFR|AMR|EUR: 4|7|7 Minor allele count:  A=0.044/97 Comment on frequency:  Low frequency (<10% in all tested populations) SNP accession:  rs17104742 Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism Species:  Human Amino acid change:  A144V Global MAF (%):  7 Subpopulation MAF (%):  AFR|AMR|ASN: 18|7|6 Minor allele count:  A=0.067/147 SNP accession:  rs7713676 Validation:  1000 Genomes, HapMap, Frequency

General Comments
Both human and mouse GPR151 lack the well-conserved D-R-Y motif downstream of the third transmembrane domain [1].