Gene and Protein Information
class A G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	336	Xp11.4	GPR82	G protein-coupled receptor 82
Mouse	6	328	X A1.1	Gpr82	G protein-coupled receptor 82
Gene and Protein Information Comments
There is no evidence for Gpr82 in rats

Database Links
Specialist databases
GPCRdb	gpr82_human (Hs), gpr82_mouse (Mm)
Other databases
Alphafold	Q96P67 (Hs), Q8BZR0 (Mm)
ChEMBL Target	CHEMBL4523907 (Hs)
Ensembl Gene	ENSG00000171657 (Hs), ENSMUSG00000047678 (Mm)
Entrez Gene	27197 (Hs), 319200 (Mm)
Human Protein Atlas	ENSG00000171657 (Hs)
KEGG Gene	hsa:27197 (Hs), mmu:319200 (Mm)
OMIM	606924 (Hs)
Pharos	Q96P67 (Hs)
RefSeq Nucleotide	NM_080817 (Hs), NM_175669 (Mm)
RefSeq Protein	NP_543007 (Hs), NP_783600 (Mm)
UniProtKB	Q96P67 (Hs), Q8BZR0 (Mm)
Wikipedia	GPR82 (Hs)

Tissue Distribution
Ubiquitously expressed in the brain, microglia, spleen and bone-marrow-derived dendritic cells. Highly expressed in the epididymis, testis and hypothalamus. Species:  Mouse Technique:  RT-PCR References:  1
Tissue Distribution Comments
Lee et al. reported that no transcripts of GPR82 were detected by Northern blot analysis in the human frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus, pons and liver tissue [2].

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Consequences of Altering Gene Expression
Mice with Gpr82 knockout have a lower body weight and body fat content associated with a reduced food intake. In addition, mice with Gpr82 knockout show decreased serum triglyceride levels, higher insulin sensitivity and glucose tolerance. Species:  Mouse Tissue:  Technique:  Knock-out by homologous recombination in embryonic stem cells References:  1

Phenotypes, Alleles and Disease Models	Mouse data from MGI
Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Gpr82tm1Lex Gpr82tm1Lex/Gpr82tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:2441734  MP:0002169 no abnormal phenotype detected

General Comments
GPR82 belongs to the group of P2Y12-like receptors [1].